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Plant-Derived Marijuana Medicine Now Available in Us Pharmacies

Washington, DC: Epidiolex, a prescription medicine containing a standardized formulation of the plant-derived cannabidiol (CBD), is now available in pharmacies in all 50 states.

The US Food and Drug Administration approved the product in June for the explicit treatment of two rare forms of severe epilepsy: Lennox-Gastaut syndrome and Dravet syndrome. In September, the US Drug Enforcement Administration reclassified it from Schedule I to Schedule V – the lowest restriction classification available under federal law. Physicians, at their discretion, may also elect to prescribe the medicine “off-label” for medical conditions other than epilepsy.

An annual prescription for Epidiolex is estimated to cost $32,500 per year, a price that the manufacturer says is “in line with other FDA-approved anti-epileptic drugs.”

Epidiolex is the fourth marijuana-based medicine to receive FDA approval – joining dronabinol (aka Marinol), nabilone (aka Cesamet), and liquid synthetic THC (aka Syndros). However, Epidiolex is the first FDA-approved medicine containing plant-derived non-synthetic cannabinoids

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Cannabis Use Associated With Improved Outcomes In Bipolar Patients

Cannabis use is associated with an alleviation of clinical symptoms in patients with bipolar disorder and does not negatively impact cognitive performance, according to clinical trial data published in the journal PLoS One.

Investigators with Harvard Medical School, Tufts University, and McLean Hospital in Massachusetts assessed the impact of marijuana use on mood symptomology and cognitive function in patients with bipolar disorder.

Authors reported that marijuana use was associated with lower scores of anger, tension, and depression, as well as higher levels of vigor in BPD patients. Subjects who used marijuana also showed no significant differences in cognitive performance compared to BPD subjects who abstained from the plant. The study is the first clinical trial to assess the impact of cannabis on both mood and neuropsychological performance in BPD patients.

Researchers concluded, “The current study highlights preliminary evidence that patients with BPD who regularly smoked marijuana reported at least short-term clinical symptom alleviation following marijuana use, indicating potential mood-stabilizing properties of marijuana in at least a subset of patients with BPD.”

 


Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country Kings Garden

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Study: Cannabis Smoke Exposure Doesn’t Significantly Impact Lung Health

Los Angeles, CA: Cannabis smoke exposure is not particularly detrimental to lung health and is not associated with the onset of lung cancer, emphysema, or COPD, according to data published in the journal Chest.

Donald Tashkin of UCLA’s David Geffen School of Medicine reviewed dozens of studies assessing cannabis smoke exposure and lung health, involving thousands of subjects.

He reports: “Although regular smoking of marijuana is associated with an increased risk of symptoms of chronic bronchitis and evidence of inflammation and injury involving the larger airways, lung function findings, although mixed, do not provide compelling evidence that habitual marijuana smoking in the manner and amount that it is generally smoked increases the risk of COPD, at least at the population level. Despite the presence of carcinogens in marijuana smoke in concentrations comparable with those that are found in tobacco smoke, the weight of evidence from well-designed epidemiologic studies does not support the concept that habitual marijuana use in the manner and quantity in which it is customarily smoked, when adjusted for tobacco, is a significant risk factor for the development of lung cancer.”

Studies also failed to show a relationship between cannabis smoking and decrements in lung function, and “argue against an association of marijuana with clinically significant emphysema.”

Tashkin’s findings are similar to those of past reviews finding that cannabis smoke exposure fails to possess the same sort of significant adverse pulmonary effects as does tobacco.

Original Press Release

 


Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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Marijuana Use Associated With Lower Diabetes Risk

The past use of cannabis is significantly associated with lower odds of diabetes in adults, according to data published in the journal Drug and Alcohol Review.

Investigators with the University of Toronto assessed the association between cannabis use and diabetes in a nationally representative sample while accounting for a range of potential confounders – including lifestyle behaviors, socio-demographics, and mental health disorders.

Compared to non-users, subjects with a history of cannabis use possessed an approximately 20 percent decreased the likelihood of diabetes. Those subjects with past-year marijuana use possessed an approximately 50 percent decreased risk.

“In sum, a decreased likelihood of diabetes for both lifetime and 12-month cannabis users versus non-users was found after accounting for a range of potential confounders, including mental health disorders,” authors concluded.

Although authors cautioned that “additional epidemiological studies … are needed before protective effects of cannabis can be suggested,” the study is one of several population studies identifying a positive association between lifetime cannabis consumption and a reduced risk for diabetes.

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New Mexico: Health Secretary Balks At Medical Cannabis Expansion

Santa Fe: Health Secretary Lynn Gallagher has agreed to proposed changes in the state’s medical cannabis law that would permit patients with obstructive sleep apnea to access marijuana; but she rejected calls to expand access to patients with other debilitating conditions, including Tourette’s syndrome (TS) and opioid dependency.

“I cannot say with any degree of confidence that the use of cannabis for the treatment of opioid dependence and its symptoms would be either safe or effective,” Secretary Gallagher opined in a signed decision. She also rejected recommendations to permit the use of cannabis for the treatment of eczema, muscular dystrophy, psoriasis, or Tourette’s syndrome.

A number of case reports and clinical trials report that THC can mitigate symptoms of TS. Cannabis use has also been associated with improved outcomes in opioid-dependent subjects undergoing outpatient treatment. Among chronic pain patients enrolled in medical cannabis programs, the use of opioids typically is reduced or eliminated over time.

About Michael King Cannabis

Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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Survey: Cannabis Use Becoming Common Among Older Adults

Aurora, CO: The use of cannabis is relatively common among those over the age of 65 who reside in a legal marijuana state, according to data published in the Journal of the American Geriatrics Society.

Investigators from the University of Colorado, Anschutz Medical Campus anonymously surveyed older adults at a pair of ambulatory geriatric primary care clinics in Colorado.

Thirty-two percent of respondents reported having used cannabis following legalization, and 16 percent reported that they were current users. Subjects were most likely to report using cannabis to mitigate symptoms of pain, anxiety, and depression, or to stimulate appetite.

Authors concluded: “[O]ur survey of ambulatory older adults from Colorado demonstrated that marijuana use in this population was common. Respondents reported using recreational marijuana to target a variety of medical symptoms and conditions with few reported adverse effects. Thus, it is prudent for primary care providers of older adults to inquire specifically about marijuana use before considering prescription changes or additions.”

Separate studies find that self-reported cannabis usage among older Americans is rising dramatically and that many seniors reduce their use of prescription medications, particularly opioids, following their marijuana use. According to clinical data assessing seniors’ long-term use of cannabis, consumption is safe and is associated with a “significant improvement” in subjects’ “overall quality of life.”

 

About Michael King Cannabis

Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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Canadians Will Be Allowed to Travel With Up to 30 Grams of Cannabis

Only four months ago, Canada became the second country in the world to legalize recreational weed. Though the act passed slowly after two years of debate, this change for Canada means a new economy bolstered by marijuana. The Cannabis Act grants anyone over the age of 18 the right to possess up to one ounce of marijuana and grow up to four plants. And though this new bill still has its issues, the change has put forth new regulations for how Canadians can travel with their legal weed from province to province. This means as of October 17, when marijuana will be officially legal across The Great White North, Canadians will be allowed to fly with up to 30 grams of cannabis.

Imagining 30 Grams

30 grams of marijuana may be tough for the average consumer to imagine. It depends on the density of the bud and if it has already been rolled or ground. But bring to mind two outstretched hands and then use the imagination to fill it with loose buds. For the flower, that’s essentially what travelers can stow away in their luggage for inter-province travels. This amount seems surprisingly lenient, considering the legal state of cannabis elsewhere.  But if perhaps travelers pre-roll their stash, they can expect to bring about 60-75 joints. For someone who smokes 3-7 joints a day, that’s a two-week trip, with weed accommodated safely in their suitcase.

International Flights and Edibles—Don’t Even Try

Still, Canadian Minister of Transport Marc Garneau quickly warned against stashing that same 30 gram loot aboard an international flight. These passengers must instead abide by the laws of the country of destination.  Officials have not finalized consequences for people who bring weed through security on international flights. And though many US states now have legal marijuana, the drug remains illegal federally. Further, the U.S. government may ban investors and employees of cannabis companies from entering the United States.

Flowers could stink up a suitcase and travelers should resist the urge to pack less fragrant edibles. After all, edibles didn’t make it through this round of legalization. And though the edible scene in Canada now exists as a grey market, it definitely won’t be cleared through security. In short, travelers should feel comfortable packing up a 30 gram supply only if headed to another Canadian province—and only if it isn’t an edible.

Pot, Province by Province

But just because the domestic skies of Canada now allow cannabis, it doesn’t mean that each province has the same regulations. In fact, many of these areas of Canada differ concerning marijuana use. The amount, price, how to sell or market and the penalties for misuse all depend on the province. For instance, the consequences of driving under the influence in Nova Scotia appear much more severe than in Quebec.

Finally, comparing the price from province to province may be a good idea before packing up for traveling, if looking to save time or money. Say the bud costs less at the destination. Pack lighter and stow the maximum allotment on the return flight. Knowing these laws can help cannabis users make informed decisions about their newly legal usage.

Waiting for October 17, 2018

In less than two weeks, Canada will be the second country after Uruguay to legalize recreational marijuana. Until then, travelers should keep the pre-rolled joints and bags of flowers from their suitcases. But on that long-awaited day, whether a cannabis user in Montreal or Winnipeg, Toronto or Vancouver, travelers can confidently stand in domestic security lines at the airport. And unlike mostly anywhere else in the world, they can do so with up to 30 grams of weed in their carry-on.

About Michael King Cannabis

Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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Daily Cannabis Use Associated With Grater Retention Rates Among Subjects Undergoing Opioid Agonist Treatment

Daily cannabis users undergoing therapy for opioid dependence are far more likely to complete their treatment regimen than are non-users, according to clinical trial data published in the journal Addiction.

Canadian investigators assessed retention rates among 820 subjects enrolled in either methadone or buprenorphine/naloxone-based treatment programs. Researchers reported, “[I]ndividuals initiating OAT (opioid agonist treatment) were approximately 21 percent more likely to be retained in treatment at six months if they reported ≥ daily use of cannabis. This finding persisted after adjustment for a range of confounders.”

They concluded, “Given the well-known mortality risk reduction benefit of sustained engagement in OAT, findings from the present study alongside prior research evidence support the urgent need for clinical research to evaluate the therapeutic potential of cannabinoids as adjunctive treatment to OAT to address the escalating opioid-overdose epidemic.”

Prior observational studies have consistently reported lower rates of opioid abuse and mortality in jurisdictions where marijuana access is legal.

For more information, contact Paul Armentano, NORML Deputy Director, at: paul@norml.org. Full text of the study, “High-intensity cannabis use is associated with retention in opioid agonist treatment: a longitudinal analysis,” appears in Addiction. NORML’s fact-sheet, “Relationship between marijuana and opioids,” is online.

Original Press Release

 

About Michael King Cannabis

Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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New Mexico: Health Secretary Balks At Medical Cannabis Expansion

Santa Fe: Health Secretary Lynn Gallagher has agreed to proposed changes in the state’s medical cannabis law that would permit patients with obstructive sleep apnea to access marijuana; but she rejected calls to expand access to patients with other debilitating conditions, including Tourette’s syndrome (TS) and opioid dependency.

“I cannot say with any degree of confidence that the use of cannabis for the treatment of opioid dependence and its symptoms would be either safe or effective,” Secretary Gallagher opined in a signed decision. She also rejected recommendations to permit the use of cannabis for the treatment of eczema, muscular dystrophy, psoriasis, or Tourette’s syndrome.

A number of case reports and clinical trials report that THC can mitigate symptoms of TS. Cannabis use has also been associated with improved outcomes in opioid-dependent subjects undergoing outpatient treatment. Among chronic pain patients enrolled in medical cannabis programs, the use of opioids typically is reduced or eliminated over time.

Original Press Release

 

About Michael King Cannabis

Michael King is an experienced cannabis professional out of Palm Springs with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country.

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Canadian Cannabis Company Captor Capital Buys San Jose Dispensary for $6 Million

Leading Santa Cruz Dispensary Acquired by Captor Capital

Adding Chai Cannabis continues to increase presence in California retail cannabis market September 18, 2018

TORONTO, Sept. 18, 2018 (GLOBE NEWSWIRE) — Captor Capital Corp. (“Captor” or the “Company”) (CSE: CPTR; FRANKFURT: NMV;USOTC:NWURF) announced today it has completed its previously announced acquisition of a dispensary in Santa Cruz, California, Chai Cannabis Inc. (“Chai”). Chai also possesses a license permitting cannabis delivery within the greater Santa Cruz area. Adding this dispensary, one of the most popular in the area (unaudited revenues of USD$8.4 in 2017), is expected to materially increase total revenues from Captor’s retail cannabis investments.

Chai was acquired for a total consideration of USD$6,015,000, of which USD$4,390,950 was payable in cash closing, USD$721,800 of which was in the form of a promissory note and USD$902,250 was paid in shares of Captor. The portion of the consideration paid in Captor shares was converted into approximately C$1,187,722 and 7,662,722 Captor Shares were issued at a deemed issue price of $0.155.

Dispensary renovations are set to begin shortly that will triple Chai’s sales floor space. The newly renovated space will allow Chai to carry a much wider range of flowers, edibles, extracts, and other cannabis products. Chai will remain open during the renovations and it is not expected to impact the dispensary’s operations. Manager of Chai, Josh Lechner, has been successfully operating the dispensary since it opened in 2014 and will continue on in this role.

The Chai brand adds a unique retail experience to the consumer which complements Captor’s premium branded MedMen (MMEN.CN), stores in West Hollywood and Santa Ana. The acquisition of Chai continues Captor’s business plan to aggressively invest in California’s retail; cannabis industry. Captor’s investment in this profitable dispensary represents a fantastic growth opportunity. We believe the Santa Cruz area with more than 4 million tourists visiting each year will become a growing retail cannabis market.”

About Captor Capital

Captor Capital Corp. is a Canadian firm focused on the cannabis sector listed on the Canadian Securities Exchange, the OTC, and the Frankfurt Stock Exchange. A vertically integrated cannabis company, Captor provides recreational and medical marijuana based products to consumers via its leading brands and dispensary locations. Listed on the Canadian Securities Exchange, the OTCUSA, and the Frankfurt Stock Exchange, Captor owns and operates advanced growing facilities which produce consistent high-quality contaminant free marijuana for its customers, as well as other high demand cannabis-based goods for consumption. 
The company follows a strategy of acquiring cash flowing established companies and organizations with growth potential that require capital to scale. Captor currently has a number of revenue generating cannabis investments including two wholly owned branded MedMen dispensaries – the world famous West Hollywood location and the showpiece Orange County dispensary in Santa Ana. Captor Capital is currently looking at additional revenue generating investments in the cannabis space and will be updating the market in due course.

 

Original Press Release


About Michael King

Michael King is an experienced professional with a background in finance, private equity, real estate and consulting. He is currently a principal in one of the leading Cannabis consulting firms in the country based out of Palm Springs — Kings Garden Inc.

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